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CLINICALTRIALSFUNDEDBYTHENATIONALMSSOCIETYUpdatedAugust2018AbbreviationsKey:CIS-afirstepisodeofneurologicsymptomsCOMP/ALT–interventionsconsideredtobeoutsidetherealmofconventionalmedicineMED–medicaltherapy,includingmedicationsandmedicalproceduresPP–primaryprogressiveMSREHAB–rehabilitationinterventionRR-relapsing-remittingMSSP-secondaryprogressiveMSProgressive-anytypeofprogressiveMSsuchasprimaryprogressive,secondaryprogressiveorprogressiverelapsingAgentTYPEOFINTER-VENTIONRE-SEARCHSTRATEGYPURPOSEOFSTUDYLEADINVESTI-GATORLEADUNIVERSITYORCOMPANYTYPEOFMS/NUMBEROFSUBJECTSSTATUS/RESULTSAcceptanceandcommitmenttherapyREHABRestoreimprovecopingIvanMoltonUniversityofWashington,SeattleAlltypes/50Completed(resultsnotreportedyet).
AcupunctureCOMP/ALTRestoreimprovesymptomsHerbertKarpatkinHunterCollege,NewYork,NYAlltypes/30Recruiting;readmore,https://clinicaltrials.
gov/ct2/show/NCT03174379AcuteintermittenthypoxiaREHABRestoreimprovemotorfunctionSherriLaVelaChicagoAssociationforResearchandEducationinScience,Chicago,ILAlltypes/10Ongoing,nofurtherinformationavailable.
AerobicexerciseREHABRestoreimprovecognitivefunctionCharlesBombardierUniversityofWashington,SeattleAlltypes/125Recruiting;readmore:http://clinicaltrials.
gov/show/NCT02106052AnticipatoryposturalcontrolREHABRestoreimprovebalanceAlexanderAruinUniversityofIllinoisatChicagoRR/20Ongoing,nofurtherinformationavailable.
AtomoxetineMEDRestoreimprovememoryJamesSumowskiIcahnSchoolofMedicineatMountSinai,NewYork,NYAlltypes/15Completed(resultsnotreportedyet).
AgentTYPEOFINTER-VENTIONRE-SEARCHSTRATEGYPURPOSEOFSTUDYLEADINVESTI-GATORLEADUNIVERSITYORCOMPANYTYPEOFMS/NUMBEROFSUBJECTSSTATUS/RESULTSBalanceandeyemovementexercisesREHABRestoreimprovestabilityandreducefatigueJeffreyHebertUniversityofColorado,DenverAlltypes/88Completed;improvedbalance,fatigue,cognition,dizzinessandqualityoflife;readmorehttps://www.
nationalmssociety.
org/About-the-Society/News/Researchers-Funded-by-National-MS-Society-Show-BalBehavioralpaininterventionREHABRestorereducepaincatastro-phizingKevinAlschulerUniversityofWashington,SeattleAlltypes/40Completed(resultsnotreportedyet).
BileacidsupplementationCOMP/ALTStopreducediseaseactivityPavanBhargavaJohnsHopkinsUniversitySchoolofMedicine,Baltimore,MDSP,PP/60Recruiting;readmore,https://clinicaltrials.
gov/ct2/show/NCT03423121CognitivetherapyREHABRestorereducepainDawnEhdeUniversityofWashington,SeattleAlltypes/240Ongoing,nofurtherinformationavailable.
CognitivetherapyREHABRestoreimprovesleepqualityandreducefatigueCatherineSiengsukonUniversityofKansasMedicalCenter,KansasCity,KSAlltypes/60Recruiting;readmore,https://clinicaltrials.
gov/ct2/show/NCT03216889Comp-ensatorysteptrainingREHABRestorepreventfallingK.
BoForemanUniversityofUtah,SaltLakeCityRR/10Completed;subtleimprovementsreported;readmore,p.
172,https://silkstart.
s3.
amazonaws.
com/59415e0f68621305b714ddfc.
pdfDalfampridineandphysicaltherapyMED/REHABRestoreimprovegaitproblemsPrudencePlummerUniversityofNorthCarolina,ChapelHillAlltypes/10Completed;improvedgaitspeed;readmorehttp://ijmsc.
org/doi/pdf/10.
7224/1537-2073.
2017-074Danceintervention,balletREHABRestoreimprovebalance,agility,andsmoothnessofmovementduringwalkingCitlaliLopez-OrtizUniversityofIllinoisatUrbana-ChampaignAlltypes/14Completed;significantimprovementsinallmeasures;readmorehttps://link.
springer.
com/chapter/10.
1007/978-3-319-46669-9_174Deprexis(internet-basedcognitivebehavioraltherapy)REHABRestorereducedepressionStefanGoldChariteUniversity,Berlin,GermanyAlltypes/400Recruiting;readmorehttps://clinicaltrials.
gov/ct2/show/NCT02740361AgentTYPEOFINTER-VENTIONRE-SEARCHSTRATEGYPURPOSEOFSTUDYLEADINVESTI-GATORLEADUNIVERSITYORCOMPANYTYPEOFMS/NUMBEROFSUBJECTSSTATUS/RESULTSDietCOMP/ALTRestoreimprovehealthandwellnessIlanaKatzSandIcahnSchoolofMedicineatMountSinai,NewYork,NYAlltypes/30Ongoing,notrecruiting;readmorehttps://clinicaltrials.
gov/ct2/show/NCT02986893DietCOMP/ALTRestorereducefatigueTerryWahlsUniversityofIowa,IowaCityRR/100Recruiting;readmorehttps://clinicaltrials.
gov/ct2/show/NCT02914964Diet(intermittentcalorierestriction)COMP/ALTStopexamineeffectsonweightandpatientreportedoutcomesEllenMowryJohnsHopkinsUniversitySchoolofMedicine,Baltimore,MDAlltypes/36Completed;nosignificantadverseeventsandsignificantimprovementsinemotionalwell-being/depressionscores;readmore,https://www.
ncbi.
nlm.
nih.
gov/pubmed/29753994Diet(intermittentcalorierestriction)COMP/ALTStopdetermineeffectsofdietonleptinandadipnecticlevels,immunesystemactivity,andcompositionofgutbacteriaLauraPiccioWashingtonUniversitySchoolofMedicine,St.
LouisRelapsing/60Recruiting;readmorehttps://www.
clinicaltrials.
gov/ct2/show/NCT03539094Dietaryinterventiondeliveredthroughweb-basedplatformCOMP/ALTRestoreexaminefeasibilityandimprovesymptomsBrooksWingoUniversityofAlabamaatBirminghamRR/20Recruiting;readmore,https://clinicaltrials.
gov/ct2/show/NCT03372187Disease-modifyingtherapiesMEDStopdeterminebestpracticesfordis-continuingtherapyJohnCorboyUniversityofColorado,DenverRelapsing/300MainlyfundedbyPCORIwithadditionalfundingfromtheNationalMSSociety.
Recruiting;readmore,https://clinicaltrials.
gov/ct2/show/NCT03073603DualtasktrainingREHABRestoreimprovewalkingJacobSosnoffUniversityofIllinoisatUrbana-ChampaignAlltypes/20Completed;trendtoimprovementinwalkingnochangeincognitivefunction;readmore,https://www.
ncbi.
nlm.
nih.
gov/pubmed/28933609AgentTYPEOFINTER-VENTIONRE-SEARCHSTRATEGYPURPOSEOFSTUDYLEADINVESTI-GATORLEADUNIVERSITYORCOMPANYTYPEOFMS/NUMBEROFSUBJECTSSTATUS/RESULTSEmotionalprocessinginterventionREHABRestoreimproveemotionalfunctionHelenGenovaKesslerFoundationResearchCenter,WestOrange,NJRR/50Recruiting;readmorehttps://clinicaltrials.
gov/ct2/show/NCT03373344E-support(onlinesupportgroup)REHABRestoreimprovepsycho-socialsymptomsVictoriaLeavittColumbiaUniversity,NewYork,NYAlltypes/36Recruiting;readmorehttps://www.
clinicaltrials.
gov/ct2/show/NCT03574961ExerciseREHABRestoreimprovebrainhealthAudreyHicksMcMasterUniversity,Hamilton,Ontario,CanadaAlltypes/30Ongoing,nofurtherinformationavailable.
ExoskeletonREHABRestoreimprovewalkingShuo-HsiuChangTheUniversityofTexasHealthScienceCenter,HoustonAlltypes/10Ongoing,nofurtherinformationavailable.
ExoskeletonREHABRestoreimprovewalkingAllanKozlowskiIcahnSchoolofMedicineatMountSinai,NewYork,NYAlltypes/12Completed;safeandfeasible,participantswhowalkedroutinelyimproved;readmorehttps://www.
ncbi.
nlm.
nih.
gov/pubmed/28315666FallpreventionprogramREHABRestorepreventfallingLauraRiceUniversityofIllinoisatUrbana-ChampaignNon-ambulatory/120Ongoing,nofurtherinformationavailable.
FeedbackpresentationREHABRestorereducefatigueEkaterinaDobryakovaKesslerFoundationResearchCenter,WestOrange,NJAlltypes/35Completed;decreasedfatigue;readmore,https://www.
ncbi.
nlm.
nih.
gov/pubmed/28627957FunctionalelectricalstimulationcyclingREHABRestorereducevascularconditionsEmersonSebastiāoUniversityofIllinoisatUrbana-ChampaignAlltypes/60Completed;resultssuggestthatactivecyclingwithFEScanelicitasufficientstimulusforimprovingcardiorespiratoryfitness;readmore,https://www.
ncbi.
nlm.
nih.
gov/pubmed/28881147FunctionalelectricalstimulationcyclingwithwebsiteandchatsessionsREHABRestoreimprovefitnessandreducevasculardiseaseLaraPiluttiUniversityofOttawa,Ontario,CAAlltypes/60Ongoing,nofurtherinformationavailable.
AgentTYPEOFINTER-VENTIONRE-SEARCHSTRATEGYPURPOSEOFSTUDYLEADINVESTI-GATORLEADUNIVERSITYORCOMPANYTYPEOFMS/NUMBEROFSUBJECTSSTATUS/RESULTSGaittrainingREHABRestoreimprovewalkingPeterAltenburgerIndianaUniversity,IndianapolisSP,PP/20Ongoing,nofurtherinformationavailable.
GazeandposturalstabilitytrainingREHABRestoreimprovebalanceandvisionstabilityLeeDibbleUniversityofUtah,SaltLakeCityAlltypes/50Recruiting;readmore,https://clinicaltrials.
gov/ct2/show/NCT03521557GlucoseregulationMEDStopdecreaserelapseseverityorimproverecoveryfromrelapseMylaGoldmanUniversityofVirginia,CharlottesvilleCIS,RR/160Recruiting;readmorehttps://clinicaltrials.
gov/ct2/show/NCT03004079IbudilastMEDStopprotectnervoussystemandstopprogressionRobertFoxClevelandClinicFoundation,OHSP,PP/250FundedwiththeNationalInstitutesofNeurologicalDisordersandStroke,withaddedsupportbyMediciNova,thesupplierofibudilast.
Completed;welltoleratedandsignificantlyslowedtherateofbrainatrophycomparedtoplacebo;readmorehttps://www.
nationalmssociety.
org/About-the-Society/News/Results-Announced-from-Phase-2-Clinical-Trial-of-IInspiratorymuscletrainingREHABRestorereducebreathingproblemsMin-HuiHangRegentsoftheUniversityofMichigan,Flint,MIAlltypes/40Recruiting;readmore,https://clinicaltrials.
gov/ct2/show/NCT03345199Internet-basedprogramtoincreasephysicalactivityREHABRestoreimprovephysicalactivity,walkingability,qualityoflife,andreducefatigue,depression,painRobertMotlUniversityofAlabamaatBirminghamRR/280Recruiting;readmorehttps://www.
clinicaltrials.
gov/ct2/show/NCT03490240KetamineMEDRestorereducefatigueBardiaNourbakhshJohnsHopkinsUniversitySchoolofMedicine,Baltimore,MDAlltypes/18Notyetrecruiting;readmore,https://www.
clinicaltrials.
gov/ct2/show/NCT03500289AgentTYPEOFINTER-VENTIONRE-SEARCHSTRATEGYPURPOSEOFSTUDYLEADINVESTI-GATORLEADUNIVERSITYORCOMPANYTYPEOFMS/NUMBEROFSUBJECTSSTATUS/RESULTSLighttherapyREHABRestorereducefatigueFarrahMateenMassachusettsGeneralHospital,BostonRR/80Recruiting;readmorehttps://clinicaltrials.
gov/ct2/show/NCT03060759LighttherapyREHABRestorereducemusclefatigueJeri-AnneLyonsUniversityofWisconsin-Milwaukee,Milwaukee,WIRR/30Ongoing,nofurtherinformationavailable.
LipoicacidCOMP/ALTRestorepreventprogressionRebeccaSpainOregonHealth&ScienceUniversity,PortlandSP,PP/118Recruiting;readmore,https://clinicaltrials.
gov/ct2/show/NCT03161028LipoicAcidandOmega-3FattyAcidsCOMP/ALTRestoreimprovecognitivefunctionLynneShintoOregonHealth&ScienceUniversity,PortlandRR,SP/53Completed;nosignificantdifferencebetweentreatmentandplacebo;readmore,https://clinicaltrials.
gov/ct2/show/results/NCT02133664LiothyronineMEDRestoretestsafetyandeffectsonsymptomsandnervecellsScottNewsomeJohnsHopkinsUniversitySchoolofMedicine,Baltimore,MDAlltypes/20Completed(resultsnotreportedyet).
LungvolumerecruitmentREHABRestoreimproverespiratoryfunctionNadimSrourUniversityofOttawa,Ontario,CAAlltypes/35Completed(resultsnotreportedyet).
ManualizedcognitiverehabilitationprogramREHABRestoreimprovememoryandtheabilitytoperformactivitiesMichaelBassoUniversityofTulsa,OKAlltypes/20Ongoing,nofurtherinformationavailable.
MeditationCOMP/ALTRestoreimproveemotionalfunctionRuchikaPrakashOhioStateUniversity,ColumbusRR/24Completed(resultsnotreportedyet).
Methyl-phenidateMEDRestorereducecognitivefatigueJohnDeLucaKesslerFoundationResearchCenter,WestOrange,NJAlltypes/36Ongoing,nofurtherinformationavailable.
AgentTYPEOFINTER-VENTIONRE-SEARCHSTRATEGYPURPOSEOFSTUDYLEADINVESTI-GATORLEADUNIVERSITYORCOMPANYTYPEOFMS/NUMBEROFSUBJECTSSTATUS/RESULTSMSSMART(threetherapieswithnerve-protectingpotential:fluoxetine,Amiloride,andRiluzole)MEDStopsloworstopMSprogressionMSClinicalTrialsNetworkestablishedbytheMSSocietyintheUnitedKingdomUniversityCollegeandothers,London,UKSP/440FundedwiththeU.
K.
MSSociety.
Ongoing,notrecruiting;readmorehttp://clinicaltrials.
gov/show/NCT01910259Multi-modalexerciseprogramREHABRestorereduceprogressionofmobilitydisabilityRobertMotlUniversityofAlabamaatBirminghamAlltypes/83Completed;significantimprovementsinendurancewalkingperformanceandcognitiveprocessingspeed;readmore,https://www.
ncbi.
nlm.
nih.
gov/pubmed/28732757PositiveairwaypressuretherapyREHABRestoreimprovecognitivefunctioninpeoplewithsleepapneaTiffanyBraleyUniversityofMichigan,AnnArborAlltypes/175Recruiting;readmorehttps://clinicaltrials.
gov/ct2/show/NCT02544373RituximabMEDStopevaluatesafetyandeffectsonmarkersofinflam-mationPeterCalabresiJohnsHopkinsUniversitySchoolofMedicine,Baltimore,MDSP,PP/12FundedjointlywithotherInternationalProgressiveMSAlliancemembers.
Completed;noseriousadverseevents,butdidnotreducemeningealBcellclustersseenonMRI;readmore,https://actrims.
confex.
com/actrims/2018/meetingapp.
cgi/Paper/2548Rituximabwithcerebralmicro-dialysisMEDStoptestsafetyandstudyimmunemessengerchemicalsinsidethebrainAndersSvennings-sonUmeUniversity,SwedenSP,PP/20FundedjointlywithotherInternationalProgressiveMSAlliancemembers.
Completed;depletesperipheralbloodBlymphocytes;readmore,https://www.
ncbi.
nlm.
nih.
gov/pmc/articles/PMC4345631/SimvastatinMEDStoptestabilitytoprotectnervoussystemJeremyChatawayUniversityCollegeandothers,London,UKSP/1180FundedjointlywithNationalInstituteforHealthResearch(U.
K.
)andMSSociety(U.
K.
).
Notyetrecruiting;readmorehttps://clinicaltrials.
gov/ct2/show/NCT03387670AgentTYPEOFINTER-VENTIONRE-SEARCHSTRATEGYPURPOSEOFSTUDYLEADINVESTI-GATORLEADUNIVERSITYORCOMPANYTYPEOFMS/NUMBEROFSUBJECTSSTATUS/RESULTSSpeechrecognitiontechnologyREHABRestoreimprovecom-munication-relatedqualityoflifeCailaVaughnTheStateUniversityofNewYorkatBuffalo,Buffalo,NYAlltypes,withdysarthria/20Ongoing,nofurtherinformationavailable.
SpeedofprocessingtrainingREHABRestoreimprovecognitivefunctionNancyChiaravallotiKesslerFoundationResearchCenter,WestOrange,NJAlltypes/100Recruiting;readmore,https://clinicaltrials.
gov/ct2/show/NCT02301260SpeedofprocessingtrainingREHABRestoreimprovecognitivefunctionBonnieGlanzBrighamandWomen'sHospital,Boston,MAAlltypes/30Completed(resultsnotreportedyet).
Steptrackingversuswaterintake-trackingREHABRestoreimprovecognitivefunctionRuchikaPrakashOhioStateUniversity,ColumbusRR/200Recruiting;readmore,https://clinicaltrials.
gov/ct2/show/NCT03244696Telehealthself-managementInterventionREHABRestorereducefatigueandincreasephysicalactivityMatthewPlowClevelandClinicFoundation,OHAlltypes/215Ongoing,notrecruiting;readmore,https://www.
nationalmssociety.
org/About-the-Society/News/MS-Trial-Alert-People-with-MS-in-Seven-States-BeinTelephone-deliveredphysicalactivityinterventionREHABRestoreimprovefatigueNoraFritzWayneStateUniversity,Detroit,MIRR/20Ongoing,nofurtherinformationavailable.
TissueselectiveestrogencomplexMEDStopimprovemenopauseandMSsymptomsRileyBoveUniversityofCalifornia,SanFranciscoAlltypes,menopausalwomen/24Recruiting;readmorehttps://clinicaltrials.
gov/ct2/show/NCT02710214TranscranialDirectCurrentStimulationREHABRestoreimprovecognition,fatigueLeighCharvetNewYorkUniversityAlltypes/60Recruiting;readmorehttps://clinicaltrials.
gov/ct2/show/NCT02746705TranscranialDirectCurrentStimulationREHABRestoreimprovewalkingThorstenRudroffColoradoStateUniversity,FortCollins,COAlltypes/30Ongoing,nofurtherinformationavailable.
AgentTYPEOFINTER-VENTIONRE-SEARCHSTRATEGYPURPOSEOFSTUDYLEADINVESTI-GATORLEADUNIVERSITYORCOMPANYTYPEOFMS/NUMBEROFSUBJECTSSTATUS/RESULTSVirtualreality-treadmillinterventionREHABRestoreimprovemobilityandcognitivefunctionJeffreyHausdorffTelAvivSouraskyMedicalCenter,TelAviv,IsraelRR/144Ongoing,nofurtherinformationavailable.
VitaminDREHABRestorepreventdevelop-mentofMSHamishCampbellMSResearchAustraliaCIS/240LargelyfundedbyMSResearchAustralia;Ongoing,readmore,https://msra.
org.
au/vitamin-d-ms-prevention-trial-prevanz/VitaminD+glatirameracetate(Copaxone,TevaPharma-ceuticalIndustries,Ltd.
)MEDStoptestsafetyandeffective-nessinreducingdiseaseactivityEllenM.
MowryJohnsHopkinsUniversitySchoolofMedicine,Baltimore,MDRR/172Recruiting;readmorehttp://clinicaltrials.
gov/ct2/show/NCT01490502WorkingmemorytrainingREHABRestoreimprovememoryJanetShucardStateUniversityofNewYork,BuffaloRR/90Ongoing,nofurtherinformationavailable.
AcupunctureCOMP/ALTRestoreimprovesymptomsHerbertKarpatkinHunterCollege,NewYork,NYAlltypes/30Recruiting;readmore,https://clinicaltrials.
gov/ct2/show/NCT03174379AcuteintermittenthypoxiaREHABRestoreimprovemotorfunctionSherriLaVelaChicagoAssociationforResearchandEducationinScience,Chicago,ILAlltypes/10Ongoing,nofurtherinformationavailable.
AerobicexerciseREHABRestoreimprovecognitivefunctionCharlesBombardierUniversityofWashington,SeattleAlltypes/125Recruiting;readmore:http://clinicaltrials.
gov/show/NCT02106052AnticipatoryposturalcontrolREHABRestoreimprovebalanceAlexanderAruinUniversityofIllinoisatChicagoRR/20Ongoing,nofurtherinformationavailable.
AtomoxetineMEDRestoreimprovememoryJamesSumowskiIcahnSchoolofMedicineatMountSinai,NewYork,NYAlltypes/15Completed(resultsnotreportedyet).
AgentTYPEOFINTER-VENTIONRE-SEARCHSTRATEGYPURPOSEOFSTUDYLEADINVESTI-GATORLEADUNIVERSITYORCOMPANYTYPEOFMS/NUMBEROFSUBJECTSSTATUS/RESULTSBalanceandeyemovementexercisesREHABRestoreimprovestabilityandreducefatigueJeffreyHebertUniversityofColorado,DenverAlltypes/88Completed;improvedbalance,fatigue,cognition,dizzinessandqualityoflife;readmorehttps://www.
nationalmssociety.
org/About-the-Society/News/Researchers-Funded-by-National-MS-Society-Show-BalBehavioralpaininterventionREHABRestorereducepaincatastro-phizingKevinAlschulerUniversityofWashington,SeattleAlltypes/40Completed(resultsnotreportedyet).
BileacidsupplementationCOMP/ALTStopreducediseaseactivityPavanBhargavaJohnsHopkinsUniversitySchoolofMedicine,Baltimore,MDSP,PP/60Recruiting;readmore,https://clinicaltrials.
gov/ct2/show/NCT03423121CognitivetherapyREHABRestorereducepainDawnEhdeUniversityofWashington,SeattleAlltypes/240Ongoing,nofurtherinformationavailable.
CognitivetherapyREHABRestoreimprovesleepqualityandreducefatigueCatherineSiengsukonUniversityofKansasMedicalCenter,KansasCity,KSAlltypes/60Recruiting;readmore,https://clinicaltrials.
gov/ct2/show/NCT03216889Comp-ensatorysteptrainingREHABRestorepreventfallingK.
BoForemanUniversityofUtah,SaltLakeCityRR/10Completed;subtleimprovementsreported;readmore,p.
172,https://silkstart.
s3.
amazonaws.
com/59415e0f68621305b714ddfc.
pdfDalfampridineandphysicaltherapyMED/REHABRestoreimprovegaitproblemsPrudencePlummerUniversityofNorthCarolina,ChapelHillAlltypes/10Completed;improvedgaitspeed;readmorehttp://ijmsc.
org/doi/pdf/10.
7224/1537-2073.
2017-074Danceintervention,balletREHABRestoreimprovebalance,agility,andsmoothnessofmovementduringwalkingCitlaliLopez-OrtizUniversityofIllinoisatUrbana-ChampaignAlltypes/14Completed;significantimprovementsinallmeasures;readmorehttps://link.
springer.
com/chapter/10.
1007/978-3-319-46669-9_174Deprexis(internet-basedcognitivebehavioraltherapy)REHABRestorereducedepressionStefanGoldChariteUniversity,Berlin,GermanyAlltypes/400Recruiting;readmorehttps://clinicaltrials.
gov/ct2/show/NCT02740361AgentTYPEOFINTER-VENTIONRE-SEARCHSTRATEGYPURPOSEOFSTUDYLEADINVESTI-GATORLEADUNIVERSITYORCOMPANYTYPEOFMS/NUMBEROFSUBJECTSSTATUS/RESULTSDietCOMP/ALTRestoreimprovehealthandwellnessIlanaKatzSandIcahnSchoolofMedicineatMountSinai,NewYork,NYAlltypes/30Ongoing,notrecruiting;readmorehttps://clinicaltrials.
gov/ct2/show/NCT02986893DietCOMP/ALTRestorereducefatigueTerryWahlsUniversityofIowa,IowaCityRR/100Recruiting;readmorehttps://clinicaltrials.
gov/ct2/show/NCT02914964Diet(intermittentcalorierestriction)COMP/ALTStopexamineeffectsonweightandpatientreportedoutcomesEllenMowryJohnsHopkinsUniversitySchoolofMedicine,Baltimore,MDAlltypes/36Completed;nosignificantadverseeventsandsignificantimprovementsinemotionalwell-being/depressionscores;readmore,https://www.
ncbi.
nlm.
nih.
gov/pubmed/29753994Diet(intermittentcalorierestriction)COMP/ALTStopdetermineeffectsofdietonleptinandadipnecticlevels,immunesystemactivity,andcompositionofgutbacteriaLauraPiccioWashingtonUniversitySchoolofMedicine,St.
LouisRelapsing/60Recruiting;readmorehttps://www.
clinicaltrials.
gov/ct2/show/NCT03539094Dietaryinterventiondeliveredthroughweb-basedplatformCOMP/ALTRestoreexaminefeasibilityandimprovesymptomsBrooksWingoUniversityofAlabamaatBirminghamRR/20Recruiting;readmore,https://clinicaltrials.
gov/ct2/show/NCT03372187Disease-modifyingtherapiesMEDStopdeterminebestpracticesfordis-continuingtherapyJohnCorboyUniversityofColorado,DenverRelapsing/300MainlyfundedbyPCORIwithadditionalfundingfromtheNationalMSSociety.
Recruiting;readmore,https://clinicaltrials.
gov/ct2/show/NCT03073603DualtasktrainingREHABRestoreimprovewalkingJacobSosnoffUniversityofIllinoisatUrbana-ChampaignAlltypes/20Completed;trendtoimprovementinwalkingnochangeincognitivefunction;readmore,https://www.
ncbi.
nlm.
nih.
gov/pubmed/28933609AgentTYPEOFINTER-VENTIONRE-SEARCHSTRATEGYPURPOSEOFSTUDYLEADINVESTI-GATORLEADUNIVERSITYORCOMPANYTYPEOFMS/NUMBEROFSUBJECTSSTATUS/RESULTSEmotionalprocessinginterventionREHABRestoreimproveemotionalfunctionHelenGenovaKesslerFoundationResearchCenter,WestOrange,NJRR/50Recruiting;readmorehttps://clinicaltrials.
gov/ct2/show/NCT03373344E-support(onlinesupportgroup)REHABRestoreimprovepsycho-socialsymptomsVictoriaLeavittColumbiaUniversity,NewYork,NYAlltypes/36Recruiting;readmorehttps://www.
clinicaltrials.
gov/ct2/show/NCT03574961ExerciseREHABRestoreimprovebrainhealthAudreyHicksMcMasterUniversity,Hamilton,Ontario,CanadaAlltypes/30Ongoing,nofurtherinformationavailable.
ExoskeletonREHABRestoreimprovewalkingShuo-HsiuChangTheUniversityofTexasHealthScienceCenter,HoustonAlltypes/10Ongoing,nofurtherinformationavailable.
ExoskeletonREHABRestoreimprovewalkingAllanKozlowskiIcahnSchoolofMedicineatMountSinai,NewYork,NYAlltypes/12Completed;safeandfeasible,participantswhowalkedroutinelyimproved;readmorehttps://www.
ncbi.
nlm.
nih.
gov/pubmed/28315666FallpreventionprogramREHABRestorepreventfallingLauraRiceUniversityofIllinoisatUrbana-ChampaignNon-ambulatory/120Ongoing,nofurtherinformationavailable.
FeedbackpresentationREHABRestorereducefatigueEkaterinaDobryakovaKesslerFoundationResearchCenter,WestOrange,NJAlltypes/35Completed;decreasedfatigue;readmore,https://www.
ncbi.
nlm.
nih.
gov/pubmed/28627957FunctionalelectricalstimulationcyclingREHABRestorereducevascularconditionsEmersonSebastiāoUniversityofIllinoisatUrbana-ChampaignAlltypes/60Completed;resultssuggestthatactivecyclingwithFEScanelicitasufficientstimulusforimprovingcardiorespiratoryfitness;readmore,https://www.
ncbi.
nlm.
nih.
gov/pubmed/28881147FunctionalelectricalstimulationcyclingwithwebsiteandchatsessionsREHABRestoreimprovefitnessandreducevasculardiseaseLaraPiluttiUniversityofOttawa,Ontario,CAAlltypes/60Ongoing,nofurtherinformationavailable.
AgentTYPEOFINTER-VENTIONRE-SEARCHSTRATEGYPURPOSEOFSTUDYLEADINVESTI-GATORLEADUNIVERSITYORCOMPANYTYPEOFMS/NUMBEROFSUBJECTSSTATUS/RESULTSGaittrainingREHABRestoreimprovewalkingPeterAltenburgerIndianaUniversity,IndianapolisSP,PP/20Ongoing,nofurtherinformationavailable.
GazeandposturalstabilitytrainingREHABRestoreimprovebalanceandvisionstabilityLeeDibbleUniversityofUtah,SaltLakeCityAlltypes/50Recruiting;readmore,https://clinicaltrials.
gov/ct2/show/NCT03521557GlucoseregulationMEDStopdecreaserelapseseverityorimproverecoveryfromrelapseMylaGoldmanUniversityofVirginia,CharlottesvilleCIS,RR/160Recruiting;readmorehttps://clinicaltrials.
gov/ct2/show/NCT03004079IbudilastMEDStopprotectnervoussystemandstopprogressionRobertFoxClevelandClinicFoundation,OHSP,PP/250FundedwiththeNationalInstitutesofNeurologicalDisordersandStroke,withaddedsupportbyMediciNova,thesupplierofibudilast.
Completed;welltoleratedandsignificantlyslowedtherateofbrainatrophycomparedtoplacebo;readmorehttps://www.
nationalmssociety.
org/About-the-Society/News/Results-Announced-from-Phase-2-Clinical-Trial-of-IInspiratorymuscletrainingREHABRestorereducebreathingproblemsMin-HuiHangRegentsoftheUniversityofMichigan,Flint,MIAlltypes/40Recruiting;readmore,https://clinicaltrials.
gov/ct2/show/NCT03345199Internet-basedprogramtoincreasephysicalactivityREHABRestoreimprovephysicalactivity,walkingability,qualityoflife,andreducefatigue,depression,painRobertMotlUniversityofAlabamaatBirminghamRR/280Recruiting;readmorehttps://www.
clinicaltrials.
gov/ct2/show/NCT03490240KetamineMEDRestorereducefatigueBardiaNourbakhshJohnsHopkinsUniversitySchoolofMedicine,Baltimore,MDAlltypes/18Notyetrecruiting;readmore,https://www.
clinicaltrials.
gov/ct2/show/NCT03500289AgentTYPEOFINTER-VENTIONRE-SEARCHSTRATEGYPURPOSEOFSTUDYLEADINVESTI-GATORLEADUNIVERSITYORCOMPANYTYPEOFMS/NUMBEROFSUBJECTSSTATUS/RESULTSLighttherapyREHABRestorereducefatigueFarrahMateenMassachusettsGeneralHospital,BostonRR/80Recruiting;readmorehttps://clinicaltrials.
gov/ct2/show/NCT03060759LighttherapyREHABRestorereducemusclefatigueJeri-AnneLyonsUniversityofWisconsin-Milwaukee,Milwaukee,WIRR/30Ongoing,nofurtherinformationavailable.
LipoicacidCOMP/ALTRestorepreventprogressionRebeccaSpainOregonHealth&ScienceUniversity,PortlandSP,PP/118Recruiting;readmore,https://clinicaltrials.
gov/ct2/show/NCT03161028LipoicAcidandOmega-3FattyAcidsCOMP/ALTRestoreimprovecognitivefunctionLynneShintoOregonHealth&ScienceUniversity,PortlandRR,SP/53Completed;nosignificantdifferencebetweentreatmentandplacebo;readmore,https://clinicaltrials.
gov/ct2/show/results/NCT02133664LiothyronineMEDRestoretestsafetyandeffectsonsymptomsandnervecellsScottNewsomeJohnsHopkinsUniversitySchoolofMedicine,Baltimore,MDAlltypes/20Completed(resultsnotreportedyet).
LungvolumerecruitmentREHABRestoreimproverespiratoryfunctionNadimSrourUniversityofOttawa,Ontario,CAAlltypes/35Completed(resultsnotreportedyet).
ManualizedcognitiverehabilitationprogramREHABRestoreimprovememoryandtheabilitytoperformactivitiesMichaelBassoUniversityofTulsa,OKAlltypes/20Ongoing,nofurtherinformationavailable.
MeditationCOMP/ALTRestoreimproveemotionalfunctionRuchikaPrakashOhioStateUniversity,ColumbusRR/24Completed(resultsnotreportedyet).
Methyl-phenidateMEDRestorereducecognitivefatigueJohnDeLucaKesslerFoundationResearchCenter,WestOrange,NJAlltypes/36Ongoing,nofurtherinformationavailable.
AgentTYPEOFINTER-VENTIONRE-SEARCHSTRATEGYPURPOSEOFSTUDYLEADINVESTI-GATORLEADUNIVERSITYORCOMPANYTYPEOFMS/NUMBEROFSUBJECTSSTATUS/RESULTSMSSMART(threetherapieswithnerve-protectingpotential:fluoxetine,Amiloride,andRiluzole)MEDStopsloworstopMSprogressionMSClinicalTrialsNetworkestablishedbytheMSSocietyintheUnitedKingdomUniversityCollegeandothers,London,UKSP/440FundedwiththeU.
K.
MSSociety.
Ongoing,notrecruiting;readmorehttp://clinicaltrials.
gov/show/NCT01910259Multi-modalexerciseprogramREHABRestorereduceprogressionofmobilitydisabilityRobertMotlUniversityofAlabamaatBirminghamAlltypes/83Completed;significantimprovementsinendurancewalkingperformanceandcognitiveprocessingspeed;readmore,https://www.
ncbi.
nlm.
nih.
gov/pubmed/28732757PositiveairwaypressuretherapyREHABRestoreimprovecognitivefunctioninpeoplewithsleepapneaTiffanyBraleyUniversityofMichigan,AnnArborAlltypes/175Recruiting;readmorehttps://clinicaltrials.
gov/ct2/show/NCT02544373RituximabMEDStopevaluatesafetyandeffectsonmarkersofinflam-mationPeterCalabresiJohnsHopkinsUniversitySchoolofMedicine,Baltimore,MDSP,PP/12FundedjointlywithotherInternationalProgressiveMSAlliancemembers.
Completed;noseriousadverseevents,butdidnotreducemeningealBcellclustersseenonMRI;readmore,https://actrims.
confex.
com/actrims/2018/meetingapp.
cgi/Paper/2548Rituximabwithcerebralmicro-dialysisMEDStoptestsafetyandstudyimmunemessengerchemicalsinsidethebrainAndersSvennings-sonUmeUniversity,SwedenSP,PP/20FundedjointlywithotherInternationalProgressiveMSAlliancemembers.
Completed;depletesperipheralbloodBlymphocytes;readmore,https://www.
ncbi.
nlm.
nih.
gov/pmc/articles/PMC4345631/SimvastatinMEDStoptestabilitytoprotectnervoussystemJeremyChatawayUniversityCollegeandothers,London,UKSP/1180FundedjointlywithNationalInstituteforHealthResearch(U.
K.
)andMSSociety(U.
K.
).
Notyetrecruiting;readmorehttps://clinicaltrials.
gov/ct2/show/NCT03387670AgentTYPEOFINTER-VENTIONRE-SEARCHSTRATEGYPURPOSEOFSTUDYLEADINVESTI-GATORLEADUNIVERSITYORCOMPANYTYPEOFMS/NUMBEROFSUBJECTSSTATUS/RESULTSSpeechrecognitiontechnologyREHABRestoreimprovecom-munication-relatedqualityoflifeCailaVaughnTheStateUniversityofNewYorkatBuffalo,Buffalo,NYAlltypes,withdysarthria/20Ongoing,nofurtherinformationavailable.
SpeedofprocessingtrainingREHABRestoreimprovecognitivefunctionNancyChiaravallotiKesslerFoundationResearchCenter,WestOrange,NJAlltypes/100Recruiting;readmore,https://clinicaltrials.
gov/ct2/show/NCT02301260SpeedofprocessingtrainingREHABRestoreimprovecognitivefunctionBonnieGlanzBrighamandWomen'sHospital,Boston,MAAlltypes/30Completed(resultsnotreportedyet).
Steptrackingversuswaterintake-trackingREHABRestoreimprovecognitivefunctionRuchikaPrakashOhioStateUniversity,ColumbusRR/200Recruiting;readmore,https://clinicaltrials.
gov/ct2/show/NCT03244696Telehealthself-managementInterventionREHABRestorereducefatigueandincreasephysicalactivityMatthewPlowClevelandClinicFoundation,OHAlltypes/215Ongoing,notrecruiting;readmore,https://www.
nationalmssociety.
org/About-the-Society/News/MS-Trial-Alert-People-with-MS-in-Seven-States-BeinTelephone-deliveredphysicalactivityinterventionREHABRestoreimprovefatigueNoraFritzWayneStateUniversity,Detroit,MIRR/20Ongoing,nofurtherinformationavailable.
TissueselectiveestrogencomplexMEDStopimprovemenopauseandMSsymptomsRileyBoveUniversityofCalifornia,SanFranciscoAlltypes,menopausalwomen/24Recruiting;readmorehttps://clinicaltrials.
gov/ct2/show/NCT02710214TranscranialDirectCurrentStimulationREHABRestoreimprovecognition,fatigueLeighCharvetNewYorkUniversityAlltypes/60Recruiting;readmorehttps://clinicaltrials.
gov/ct2/show/NCT02746705TranscranialDirectCurrentStimulationREHABRestoreimprovewalkingThorstenRudroffColoradoStateUniversity,FortCollins,COAlltypes/30Ongoing,nofurtherinformationavailable.
AgentTYPEOFINTER-VENTIONRE-SEARCHSTRATEGYPURPOSEOFSTUDYLEADINVESTI-GATORLEADUNIVERSITYORCOMPANYTYPEOFMS/NUMBEROFSUBJECTSSTATUS/RESULTSVirtualreality-treadmillinterventionREHABRestoreimprovemobilityandcognitivefunctionJeffreyHausdorffTelAvivSouraskyMedicalCenter,TelAviv,IsraelRR/144Ongoing,nofurtherinformationavailable.
VitaminDREHABRestorepreventdevelop-mentofMSHamishCampbellMSResearchAustraliaCIS/240LargelyfundedbyMSResearchAustralia;Ongoing,readmore,https://msra.
org.
au/vitamin-d-ms-prevention-trial-prevanz/VitaminD+glatirameracetate(Copaxone,TevaPharma-ceuticalIndustries,Ltd.
)MEDStoptestsafetyandeffective-nessinreducingdiseaseactivityEllenM.
MowryJohnsHopkinsUniversitySchoolofMedicine,Baltimore,MDRR/172Recruiting;readmorehttp://clinicaltrials.
gov/ct2/show/NCT01490502WorkingmemorytrainingREHABRestoreimprovememoryJanetShucardStateUniversityofNewYork,BuffaloRR/90Ongoing,nofurtherinformationavailable.
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