mg1433
1433 时间:2021-03-01 阅读:()
Reactions1433-5Jan2013SSunitinibLungtoxicity:casereportAmandevelopedlungtoxicityduringtreatmentwithsunitinib,anoraldrugusedtotreatmetastatickidneycancer.
Themanpresentedwithnightsweatsandexertionaldyspnoeain2008,at61yearsofage.
Hewasdiagnosedwithmixedconnectivetissuediseasewithpulmonaryfibrosis.
In2009,CTscansshowedatumourinhisleftkidneywithmultiplelungmetastasesandlatero-aorticlymphnodes.
Hehadahigh-grademixedrenal-cellcarcinomawithlymphnodeinvolvement.
Multiplemetastaseswereseen.
InJune2009,hewasstartedonsunitinib50mg/dayfor4weeks.
Thiswasfollowedby2weekswithouttreatment.
Hehadgoodtoleranceofthefirstcycleofsunitinib,butheexperienceddysgeusia,skindesquamation,grade1nauseaandgrade2hypertension.
Threeweeksafterstartingsunitinibtherapy,heexperiencedfeverandpain[ageatreactiononsetnotclearlystated].
Hewastreatedwithceftriaxone,buthisconditionworsened.
Hewasadmittedtointensivecarewithrenalfailureandbreathingdifficulties.
Theman'santibacterialtherapywaschangedtociprofloxacin,cotrimoxazole[trimethoprim/sulfamethoxazole]andtazobactam.
However,hisconditionworsened.
Hewasintubated,andpathologicalexaminationfindingswerecompatiblewithchroniclesionsofinterstitialfibrosisandacutelesionscompatiblewithcryptogenicorganisingpneumonia.
Hewasstartedonclarithromycinandsteroids.
Hisrespiratorystatusimproved,andhewastakenofftheventilator.
Hewasdischargedfromintensivecare,andhisconditionimproved.
Uponfollow-upinOctober2009,hehadnosignsofpneumonitis.
However,hisdiseasehadprogressed.
Hehadpainandaskedtobetreated.
Themanwasstartedonsunitinib25mg,whichwastobegivenfor3daysandstoppedfor3days.
Fourdaysafterstartingtreatment,heexperiencedseveredyspnoea.
BilateralinfiltrateswereseenwithaCTscan.
Hissteroidswereincreased,andfurosemidewasgiven.
Hisconditiondeteriorated,andhedied.
Authorcomment:"Thechronologicalorderoftheeventsseemstopointtoacausaleffectofsunitinibinthispneumonia.
Whenrechallengedwiththedrugthesymptomsreappearedquickly.
"BoyleHJ,etal.
Lungtoxicityinapatienttreatedwithsunitinib.
EuropeanRespiratoryJournal40:1300-1303,No.
5,Nov2012.
Availablefrom:URL:http://dx.
doi.
org/10.
1183/09031936.
00048212-France8030814991Reactions5Jan2013No.
14330114-9954/10/1433-0001/$14.
95Adis2010SpringerInternationalPublishingAG.
Allrightsreserved
Themanpresentedwithnightsweatsandexertionaldyspnoeain2008,at61yearsofage.
Hewasdiagnosedwithmixedconnectivetissuediseasewithpulmonaryfibrosis.
In2009,CTscansshowedatumourinhisleftkidneywithmultiplelungmetastasesandlatero-aorticlymphnodes.
Hehadahigh-grademixedrenal-cellcarcinomawithlymphnodeinvolvement.
Multiplemetastaseswereseen.
InJune2009,hewasstartedonsunitinib50mg/dayfor4weeks.
Thiswasfollowedby2weekswithouttreatment.
Hehadgoodtoleranceofthefirstcycleofsunitinib,butheexperienceddysgeusia,skindesquamation,grade1nauseaandgrade2hypertension.
Threeweeksafterstartingsunitinibtherapy,heexperiencedfeverandpain[ageatreactiononsetnotclearlystated].
Hewastreatedwithceftriaxone,buthisconditionworsened.
Hewasadmittedtointensivecarewithrenalfailureandbreathingdifficulties.
Theman'santibacterialtherapywaschangedtociprofloxacin,cotrimoxazole[trimethoprim/sulfamethoxazole]andtazobactam.
However,hisconditionworsened.
Hewasintubated,andpathologicalexaminationfindingswerecompatiblewithchroniclesionsofinterstitialfibrosisandacutelesionscompatiblewithcryptogenicorganisingpneumonia.
Hewasstartedonclarithromycinandsteroids.
Hisrespiratorystatusimproved,andhewastakenofftheventilator.
Hewasdischargedfromintensivecare,andhisconditionimproved.
Uponfollow-upinOctober2009,hehadnosignsofpneumonitis.
However,hisdiseasehadprogressed.
Hehadpainandaskedtobetreated.
Themanwasstartedonsunitinib25mg,whichwastobegivenfor3daysandstoppedfor3days.
Fourdaysafterstartingtreatment,heexperiencedseveredyspnoea.
BilateralinfiltrateswereseenwithaCTscan.
Hissteroidswereincreased,andfurosemidewasgiven.
Hisconditiondeteriorated,andhedied.
Authorcomment:"Thechronologicalorderoftheeventsseemstopointtoacausaleffectofsunitinibinthispneumonia.
Whenrechallengedwiththedrugthesymptomsreappearedquickly.
"BoyleHJ,etal.
Lungtoxicityinapatienttreatedwithsunitinib.
EuropeanRespiratoryJournal40:1300-1303,No.
5,Nov2012.
Availablefrom:URL:http://dx.
doi.
org/10.
1183/09031936.
00048212-France8030814991Reactions5Jan2013No.
14330114-9954/10/1433-0001/$14.
95Adis2010SpringerInternationalPublishingAG.
Allrightsreserved
- mg1433相关文档
- 不详1433
- Pd7Ir1433
- 中华人民共和国海事局中国沿海港口航道图改改正正通通告告第53期
- "江苏省卫生和计划生育委员会直属事业单位2019年公开招聘工作人员岗位表"
- Indicators1433
- 港元1433
LOCVPS全场8折,香港云地/邦联VPS带宽升级不加价
LOCVPS发布了7月份促销信息，全场VPS主机8折优惠码，续费同价，同时香港云地/邦联机房带宽免费升级不加价，原来3M升级至6M，2GB内存套餐优惠后每月44元起。这是成立较久的一家国人VPS服务商，提供美国洛杉矶(MC/C3)、和中国香港(邦联、沙田电信、大埔)、日本(东京、大阪)、新加坡、德国和荷兰等机房VPS主机，基于XEN或者KVM虚拟架构，均选择国内访问线路不错的机房，适合建站和远程办...
器安装环境和运维管理工具推荐
今天看到一个网友从原来虚拟主机准备转移至服务器管理自己的业务。这里问到虚拟主机和服务器到底有什么不同，需要用到哪些工具软件。那准备在下班之间稍微摸鱼一下整理我们服务器安装环境和运维管理中常见需要用到的软件工具推荐。第一、系统镜像软件一般来说，我们云服务器或者独立服务器都是有自带镜像的。我们只需要选择镜像安装就可以，比如有 Windows和Linux。但是有些时候我们可能需要自定义镜像的高级玩法，这...
美得云（20元）香港特价将军澳CTG+CN2云服务器
美得云成立于2021年，是一家云产品管理服务商（cloud）专业提供云计算服务、DDOS防护、网络安全服务、国内海外数据中心托管租用等业务、20000+用户的选择，43800+小时稳定运行香港特价将军澳CTG+CN2云服务器、采用高端CPU 优质CN2路线 SDD硬盘。香港CTG+CN22核2G3M20G数据盘25元点击购买香港CTG+CN22核2G5M30G数据盘39元点击购买香港CTG+CN...
1433为你推荐
-
怎么改ip如何修改IP地址？网站运营刚创业的网站运营怎么做？xv播放器下载除了迅雷看看播放器还有什么播放器支持xv格式的视频？畅想中国淄博畅想中国消费怎么样ios系统苹果手机的系统是什么?bluestackbluestacks安卓模拟器有什么用分词技术百度的中文分词原理是什么?与IK分词有区别吗?srv记录如何解析一个SRV域名的ip怎样申请支付宝怎样申请支付宝?怎样申请支付宝如何申请支付宝