Bioactive Components of Cordyceps taii and Their Immune
Functions in Mice
Abstract:The polysaccharide,adenosine and mannitol components of Cordycepstaii collected from the wild were determined, and the effects of aqueous C. taiiextracts on immune functions in mice were investigated using carbon clearance anddelayed type hypersensitivity testing(DTH),and by determining thymic and splenicindices. Polysaccharide, adenosine and mannitol levels in C. taii were 36.20 mg/g,
0.27 mg/g and 80.20 mg/g, respectively.Aqueous C. taii extracts partially alleviatedthe suppressive effects on the thymic and splenic indices caused bycyclophosphamide, and increased nonspecific immunity and cellular immunefunctions.Toxicity tests revealed that the LD50 for aqueous C. taii extract on oraladministration was69.42 g/kg.
Key words:Cordyceps taii;polysaccharide;adenosine;mannitol;carbonclearance;cellular immune function
Cordyceps sinensis (Berk.) Sacc. is a rare medicinal fungus in China withnumerous special pharmacological effects favoured by consumers. However, C.sinensis yields are decreasing year by year and the price of this limited resource isnow very high due to over gathering.However, other species within the genusCordyceps have often been reported to have similar chemical composition andpharmacological effects1 and might, there fore, serve as efficient sub stitutes for C.sinensis.One such alternative species is C. taii Liang et Liu which was firstlydiscovered and reported in Guizhou Province in 1991 2 and has subsequently beenfound in Anhui, Henan, Hunan and Guangdong Provinces. Comparison of thechemical composition of C. sinensis and C. taii showed that both species had similaramino ac id,vitamin and microe lement components3 .The microelement and aminoacid composition ofC. taii mycelia have also been reported 4,5 ,and extracts ofC.taii mycelia have antiseptic 6 , immunoregulatory 6~9 and tumor cell growthinhibiting functions 10 . In order to provide a basis for utilizing C. taii as analternative forC. sinensis, we have compared the levels of various bioactivecomponents in these two species,and studied the effect of aqueous C. taii extracts onnon specific immune functions, thymic and splenic indices,and cellular immunity inmic e.
1 Materials and Methods
1.1 Materials
C. taii was supplied by Guangdong Jin Cordyceps Biological Development Co.Ltd,and C. s inens is wa s purchas ed from Guangzhou Tongrentang Drugstore.
ATCLOUD.NET怎么样?ATCLOUD.NET主要提供KVM架构的VPS产品、LXC容器化产品、权威DNS智能解析、域名注册、SSL证书等海外网站建设服务。 其大部分数据中心是由OVH机房提供,其节点包括美国(俄勒冈、弗吉尼亚)、加拿大、英国、法国、德国以及新加坡。 提供超过480Gbps的DDoS高防保护,杜绝DDoS攻击骚扰,比较适合海外建站等业务。官方网站:点击访问ATCLOUD官网活...
IT狗为用户提供 在线ping、在线tcping、在线路由追踪、域名被墙检测、域名被污染检测 等实用工具。【工具地址】https://www.itdog.cn/【工具特色】1、目前同类网站中,在线ping 仅支持1次或少量次数的测试,无法客观的展现目标服务器一段时间的网络状况,IT狗Ping工具可持续的进行一段时间的ping测试,并生成更为直观的网络质量柱状图,让用户更容易掌握服务器在各地区、各线...
LOCVPS(全球云)发布了新上韩国机房KVM架构主机信息,提供流量和带宽方式,适用全场8折优惠码,优惠码最低2G内存套餐月付仅44元起。这是一家成立较早的国人VPS服务商,目前提供洛杉矶MC、洛杉矶C3、和香港邦联、香港沙田电信、香港大埔、日本东京、日本大阪、新加坡、德国和荷兰等机房VPS主机,基于KVM或者XEN架构。下面分别列出几款韩国机房KVM主机配置信息。韩国KVM流量型套餐:KR-Pl...