Bioactive Components of Cordyceps taii and Their Immune
Functions in Mice
Abstract:The polysaccharide,adenosine and mannitol components of Cordycepstaii collected from the wild were determined, and the effects of aqueous C. taiiextracts on immune functions in mice were investigated using carbon clearance anddelayed type hypersensitivity testing(DTH),and by determining thymic and splenicindices. Polysaccharide, adenosine and mannitol levels in C. taii were 36.20 mg/g,
0.27 mg/g and 80.20 mg/g, respectively.Aqueous C. taii extracts partially alleviatedthe suppressive effects on the thymic and splenic indices caused bycyclophosphamide, and increased nonspecific immunity and cellular immunefunctions.Toxicity tests revealed that the LD50 for aqueous C. taii extract on oraladministration was69.42 g/kg.
Key words:Cordyceps taii;polysaccharide;adenosine;mannitol;carbonclearance;cellular immune function
Cordyceps sinensis (Berk.) Sacc. is a rare medicinal fungus in China withnumerous special pharmacological effects favoured by consumers. However, C.sinensis yields are decreasing year by year and the price of this limited resource isnow very high due to over gathering.However, other species within the genusCordyceps have often been reported to have similar chemical composition andpharmacological effects1 and might, there fore, serve as efficient sub stitutes for C.sinensis.One such alternative species is C. taii Liang et Liu which was firstlydiscovered and reported in Guizhou Province in 1991 2 and has subsequently beenfound in Anhui, Henan, Hunan and Guangdong Provinces. Comparison of thechemical composition of C. sinensis and C. taii showed that both species had similaramino ac id,vitamin and microe lement components3 .The microelement and aminoacid composition ofC. taii mycelia have also been reported 4,5 ,and extracts ofC.taii mycelia have antiseptic 6 , immunoregulatory 6~9 and tumor cell growthinhibiting functions 10 . In order to provide a basis for utilizing C. taii as analternative forC. sinensis, we have compared the levels of various bioactivecomponents in these two species,and studied the effect of aqueous C. taii extracts onnon specific immune functions, thymic and splenic indices,and cellular immunity inmic e.
1 Materials and Methods
1.1 Materials
C. taii was supplied by Guangdong Jin Cordyceps Biological Development Co.Ltd,and C. s inens is wa s purchas ed from Guangzhou Tongrentang Drugstore.
昨天,遇到一个网友客户告知他的网站无法访问需要帮他检查到底是什么问题。这个同学的网站是我帮他搭建的,于是我先PING看到他的网站是不通的,开始以为是服务器是不是出现故障导致无法打开的。检查到他的服务器是有放在SugarHosts糖果主机商中,于是我登录他的糖果主机后台看到服务器是正常运行的。但是,我看到面板中的IP地址居然是和他网站解析的IP地址不同。看来官方是有更换域名。于是我就问 客服到底是什...
DMIT怎么样?DMIT是一家美国主机商,主要提供KVM VPS、独立服务器等,主要提供香港CN2、洛杉矶CN2 GIA等KVM VPS,稳定性、网络都很不错。支持中文客服,可Paypal、支付宝付款。2020年推出的香港国际线路的KVM VPS,大带宽,适合中转落地使用。现在有永久9折优惠码:July-4-Lite-10OFF,季付及以上还有折扣,非 中国路由优化;AS4134,AS4837 均...
Nocser刚刚在WHT发布了几款促销服务器,Intel Xeon X3430,8GB内存,1TB HDD,30M不限流量,月付$60.00。Nocser是一家注册于马来西亚的主机商,主要经营虚拟主机、VPS和马来西亚独立服务器业务,数据中心位于马来西亚AIMS机房,线路方面,AIMS到国内电信一般,绕日本NTT;联通和移动比较友好,联通走新加坡,移动走香港,延迟都在100左右。促销马来西亚服务器...