Bioactive Components of Cordyceps taii and Their Immune
Functions in Mice
Abstract:The polysaccharide,adenosine and mannitol components of Cordycepstaii collected from the wild were determined, and the effects of aqueous C. taiiextracts on immune functions in mice were investigated using carbon clearance anddelayed type hypersensitivity testing(DTH),and by determining thymic and splenicindices. Polysaccharide, adenosine and mannitol levels in C. taii were 36.20 mg/g,
0.27 mg/g and 80.20 mg/g, respectively.Aqueous C. taii extracts partially alleviatedthe suppressive effects on the thymic and splenic indices caused bycyclophosphamide, and increased nonspecific immunity and cellular immunefunctions.Toxicity tests revealed that the LD50 for aqueous C. taii extract on oraladministration was69.42 g/kg.
Key words:Cordyceps taii;polysaccharide;adenosine;mannitol;carbonclearance;cellular immune function
Cordyceps sinensis (Berk.) Sacc. is a rare medicinal fungus in China withnumerous special pharmacological effects favoured by consumers. However, C.sinensis yields are decreasing year by year and the price of this limited resource isnow very high due to over gathering.However, other species within the genusCordyceps have often been reported to have similar chemical composition andpharmacological effects1 and might, there fore, serve as efficient sub stitutes for C.sinensis.One such alternative species is C. taii Liang et Liu which was firstlydiscovered and reported in Guizhou Province in 1991 2 and has subsequently beenfound in Anhui, Henan, Hunan and Guangdong Provinces. Comparison of thechemical composition of C. sinensis and C. taii showed that both species had similaramino ac id,vitamin and microe lement components3 .The microelement and aminoacid composition ofC. taii mycelia have also been reported 4,5 ,and extracts ofC.taii mycelia have antiseptic 6 , immunoregulatory 6~9 and tumor cell growthinhibiting functions 10 . In order to provide a basis for utilizing C. taii as analternative forC. sinensis, we have compared the levels of various bioactivecomponents in these two species,and studied the effect of aqueous C. taii extracts onnon specific immune functions, thymic and splenic indices,and cellular immunity inmic e.
1 Materials and Methods
1.1 Materials
C. taii was supplied by Guangdong Jin Cordyceps Biological Development Co.Ltd,and C. s inens is wa s purchas ed from Guangzhou Tongrentang Drugstore.
mineserver怎么样?mineserver是一家国人商家,主要提供香港CN2 KVM VPS、香港CMI KVM VPS、日本CN2 KVM VPS、洛杉矶cn2 gia端口转发等服务,之前介绍过几次,最近比较活跃。这家新推出了洛杉矶CN2 GIA VPS,512MB内存/20GB NVME/800GB流量/200Mbps/KVM,58元/季,并且进行了带宽升级,同时IP更改为美国IP。点击...
CloudServer是一家新的VPS主机商,成立了差不多9个月吧,提供基于KVM架构的VPS主机,支持Linux或者Windows操作系统,数据中心在美国纽约、洛杉矶和芝加哥机房,都是ColoCrossing的机器。目前商家在LEB提供了几款特价套餐,最低月付4美元(或者$23.88/年),购买更高级别套餐还能三个月费用使用6个月,等于前半年五折了。下面列出几款特别套餐配置信息。CPU:1cor...
RepriseHosting是成立于2012年的国外主机商,提供独立服务器租用和VPS主机等产品,数据中心在美国西雅图和拉斯维加斯机房。商家提供的独立服务器以较低的价格为主,目前针对西雅图机房部分独立服务器提供的优惠仍然有效,除了价格折扣外,还免费升级内存和带宽,商家支持使用支付宝或者PayPal、信用卡等付款方式。配置一 $27.97/月CPU:Intel Xeon L5640内存:16GB(原...