Bioactive Components of Cordyceps taii and Their Immune
Functions in Mice
Abstract:The polysaccharide,adenosine and mannitol components of Cordycepstaii collected from the wild were determined, and the effects of aqueous C. taiiextracts on immune functions in mice were investigated using carbon clearance anddelayed type hypersensitivity testing(DTH),and by determining thymic and splenicindices. Polysaccharide, adenosine and mannitol levels in C. taii were 36.20 mg/g,
0.27 mg/g and 80.20 mg/g, respectively.Aqueous C. taii extracts partially alleviatedthe suppressive effects on the thymic and splenic indices caused bycyclophosphamide, and increased nonspecific immunity and cellular immunefunctions.Toxicity tests revealed that the LD50 for aqueous C. taii extract on oraladministration was69.42 g/kg.
Key words:Cordyceps taii;polysaccharide;adenosine;mannitol;carbonclearance;cellular immune function
Cordyceps sinensis (Berk.) Sacc. is a rare medicinal fungus in China withnumerous special pharmacological effects favoured by consumers. However, C.sinensis yields are decreasing year by year and the price of this limited resource isnow very high due to over gathering.However, other species within the genusCordyceps have often been reported to have similar chemical composition andpharmacological effects1 and might, there fore, serve as efficient sub stitutes for C.sinensis.One such alternative species is C. taii Liang et Liu which was firstlydiscovered and reported in Guizhou Province in 1991 2 and has subsequently beenfound in Anhui, Henan, Hunan and Guangdong Provinces. Comparison of thechemical composition of C. sinensis and C. taii showed that both species had similaramino ac id,vitamin and microe lement components3 .The microelement and aminoacid composition ofC. taii mycelia have also been reported 4,5 ,and extracts ofC.taii mycelia have antiseptic 6 , immunoregulatory 6~9 and tumor cell growthinhibiting functions 10 . In order to provide a basis for utilizing C. taii as analternative forC. sinensis, we have compared the levels of various bioactivecomponents in these two species,and studied the effect of aqueous C. taii extracts onnon specific immune functions, thymic and splenic indices,and cellular immunity inmic e.
1 Materials and Methods
1.1 Materials
C. taii was supplied by Guangdong Jin Cordyceps Biological Development Co.Ltd,and C. s inens is wa s purchas ed from Guangzhou Tongrentang Drugstore.
公司介绍成都随风云科技有限公司成立于2021年,是国内领先的互联网业务平台服务提供商。公司专注为用户提供低价高性能云计算产品,致力于云计算应用的易用性开发,并引导云计算在国内普及。目前公司研发以及运营云服务基础设施服务平台(IaaS),面向全球客户提供基于云计算的IT解决方案与客户服务,拥有丰富的国内BGP、双线高防、香港等优质的IDC资源。公司一直秉承”以人为本、客户为尊、永续创新&...
传统农历新年将至,国人主机商DogYun(狗云)发来了虎年春节优惠活动,1月31日-2月6日活动期间使用优惠码新开动态云7折,经典云8折,新开独立服务器可立减100元/月;使用优惠码新开香港独立服务器优惠100元,并次月免费;活动期间单笔充值每满100元赠送10元,还可以参与幸运大转盘每日抽取5折码,流量,余额等奖品;商家限量推出一款年付特价套餐,共100台,每个用户限1台,香港VPS年付199元...
Sharktech荷兰10G带宽的独立服务器月付319美元起,10Gbps共享带宽,不限制流量,自带5个IPv4,免费60Gbps的 DDoS防御,可加到100G防御。CPU内存HDD价格购买地址E3-1270v216G2T$319/月链接E3-1270v516G2T$329/月链接2*E5-2670v232G2T$389/月链接2*E5-2678v364G2T$409/月链接这里我们需要注意,默...