Bioactive Components of Cordyceps taii and Their Immune
Functions in Mice
Abstract:The polysaccharide,adenosine and mannitol components of Cordycepstaii collected from the wild were determined, and the effects of aqueous C. taiiextracts on immune functions in mice were investigated using carbon clearance anddelayed type hypersensitivity testing(DTH),and by determining thymic and splenicindices. Polysaccharide, adenosine and mannitol levels in C. taii were 36.20 mg/g,
0.27 mg/g and 80.20 mg/g, respectively.Aqueous C. taii extracts partially alleviatedthe suppressive effects on the thymic and splenic indices caused bycyclophosphamide, and increased nonspecific immunity and cellular immunefunctions.Toxicity tests revealed that the LD50 for aqueous C. taii extract on oraladministration was69.42 g/kg.
Key words:Cordyceps taii;polysaccharide;adenosine;mannitol;carbonclearance;cellular immune function
Cordyceps sinensis (Berk.) Sacc. is a rare medicinal fungus in China withnumerous special pharmacological effects favoured by consumers. However, C.sinensis yields are decreasing year by year and the price of this limited resource isnow very high due to over gathering.However, other species within the genusCordyceps have often been reported to have similar chemical composition andpharmacological effects1 and might, there fore, serve as efficient sub stitutes for C.sinensis.One such alternative species is C. taii Liang et Liu which was firstlydiscovered and reported in Guizhou Province in 1991 2 and has subsequently beenfound in Anhui, Henan, Hunan and Guangdong Provinces. Comparison of thechemical composition of C. sinensis and C. taii showed that both species had similaramino ac id,vitamin and microe lement components3 .The microelement and aminoacid composition ofC. taii mycelia have also been reported 4,5 ,and extracts ofC.taii mycelia have antiseptic 6 , immunoregulatory 6~9 and tumor cell growthinhibiting functions 10 . In order to provide a basis for utilizing C. taii as analternative forC. sinensis, we have compared the levels of various bioactivecomponents in these two species,and studied the effect of aqueous C. taii extracts onnon specific immune functions, thymic and splenic indices,and cellular immunity inmic e.
1 Materials and Methods
1.1 Materials
C. taii was supplied by Guangdong Jin Cordyceps Biological Development Co.Ltd,and C. s inens is wa s purchas ed from Guangzhou Tongrentang Drugstore.
这个月11号ShockHosting发了个新上日本东京机房的邮件,并且表示其他机房可以申请转移到日本,刚好赵容手里有个美国的也没数据就发工单申请新开了一个,这里做个简单的测试,方便大家参考。ShockHosting成立于2013年,目前提供的VPS主机可以选择11个数据中心,包括美国洛杉矶、芝加哥、达拉斯、杰克逊维尔、新泽西、澳大利亚、新加坡、日本、荷兰和英国等。官方网站:https://shoc...
LayerStack(成立于2017年),当前正在9折促销旗下的云服务器,LayerStack的云服务器采用第 3 代 AMD EPYC™ (霄龙) 处理器,DDR4内存和企业级 PCIe Gen 4 NVMe SSD。数据中心可选中国香港、日本、新加坡和洛杉矶!其中中国香港、日本和新加坡分为国际线路和CN2线路,如果选择CN2线路,价格每月要+3.2美元,付款支持paypal,支付宝,信用卡等!...
御云怎么样?炎炎暑期即将来临,御云(royalyun)香港、美国服务器开启大特惠模式。御云是新成立的云服务提供商,主要提供香港、美国的云服务器,不久将开启虚拟主机业务。我们的香港和美国主机采用CN2 GIA线路。目前,香港cn2 gia vps仅7.9元每月起,美国vps仅8.9/月,续费同价,可叠加优惠,香港云服务器国内延迟一般在50ms左右,是搭建网站的最佳选择,但是请不要用于违法用途。点击进...