Bioactive Components of Cordyceps taii and Their Immune
Functions in Mice
Abstract:The polysaccharide,adenosine and mannitol components of Cordycepstaii collected from the wild were determined, and the effects of aqueous C. taiiextracts on immune functions in mice were investigated using carbon clearance anddelayed type hypersensitivity testing(DTH),and by determining thymic and splenicindices. Polysaccharide, adenosine and mannitol levels in C. taii were 36.20 mg/g,
0.27 mg/g and 80.20 mg/g, respectively.Aqueous C. taii extracts partially alleviatedthe suppressive effects on the thymic and splenic indices caused bycyclophosphamide, and increased nonspecific immunity and cellular immunefunctions.Toxicity tests revealed that the LD50 for aqueous C. taii extract on oraladministration was69.42 g/kg.
Key words:Cordyceps taii;polysaccharide;adenosine;mannitol;carbonclearance;cellular immune function
Cordyceps sinensis (Berk.) Sacc. is a rare medicinal fungus in China withnumerous special pharmacological effects favoured by consumers. However, C.sinensis yields are decreasing year by year and the price of this limited resource isnow very high due to over gathering.However, other species within the genusCordyceps have often been reported to have similar chemical composition andpharmacological effects1 and might, there fore, serve as efficient sub stitutes for C.sinensis.One such alternative species is C. taii Liang et Liu which was firstlydiscovered and reported in Guizhou Province in 1991 2 and has subsequently beenfound in Anhui, Henan, Hunan and Guangdong Provinces. Comparison of thechemical composition of C. sinensis and C. taii showed that both species had similaramino ac id,vitamin and microe lement components3 .The microelement and aminoacid composition ofC. taii mycelia have also been reported 4,5 ,and extracts ofC.taii mycelia have antiseptic 6 , immunoregulatory 6~9 and tumor cell growthinhibiting functions 10 . In order to provide a basis for utilizing C. taii as analternative forC. sinensis, we have compared the levels of various bioactivecomponents in these two species,and studied the effect of aqueous C. taii extracts onnon specific immune functions, thymic and splenic indices,and cellular immunity inmic e.
1 Materials and Methods
1.1 Materials
C. taii was supplied by Guangdong Jin Cordyceps Biological Development Co.Ltd,and C. s inens is wa s purchas ed from Guangzhou Tongrentang Drugstore.
ucloud香港服务器优惠降价活动开始了!此前,ucloud官方全球云大促活动的香港云服务器一度上涨至2核4G配置752元/年,2031元/3年。让很多想购买ucloud香港云服务器的新用户望而却步!不过,目前,ucloud官方下调了香港服务器价格,此前2核4G香港云服务器752元/年,现在降至358元/年,968元/3年,价格降了快一半了!UCloud活动路子和阿里云、腾讯云不同,活动一步到位,...
触摸云国内IDC/ISP资质齐全商家,与香港公司联合运营, 已超8年运营 。本次为大家带来的是双12特惠活动,美国高防|美国大宽带买就可申请配置升档一级[CPU内存宽带流量选一]升档方式:CPU内存宽带流量任选其一,工单申请免费升级一档珠海触摸云科技有限公司官方网站:https://cmzi.com/可新购免费升档配置套餐:地区CPU内存带宽数据盘价格购买地址美国高防 1核 1G10M20G 26...
腾讯云双十一活动已于今天正式开启了,多重优惠享不停,首购服务器低至0.4折,比如1C2G5M轻量应用服务器仅48元/年起,2C4G8M也仅70元/年起;个人及企业用户还可以一键领取3500-7000元满减券,用于支付新购、续费、升级等各项账单;企业用户还可以以首年1年的价格注册.COM域名。活动页面:https://cloud.tencent.com/act/double11我们分享的信息仍然以秒...