http://www.aqsiqccc.com/en/aqsiq/sfda-9.html
www.585ccc.com 时间:2021-03-19 阅读:()
LocationHome>ServiceProject>ApplicationandEvaluationofnewcosmeticingredientsguideDate2011-05-12CosmeticsrawmaterialsontheissuanceofnewguidelinesforthereviewofthenotificationandreportingStateFoodandDrugAdministrationXu[2011]No.
207May12,2011releaseProvinces,autonomousregionsandmunicipalitiesFoodandDrugAdministration(DrugAdministration),theunit:Newcosmeticingredientstoenhancetheadministrativelicensingworktoensurequalityandsafetyofcosmeticproducts,basedon"cosmeticsHealthSupervision"anditsImplementingRulesandotherrelevantprovisionsoftheStateFoodandDrugAdministrationtodevelopa"declarationofnewcosmeticrawmaterialsandguidelinesforthereview.
"Isherebyissued,pleasecomply.
ApplicationandEvaluationofnewcosmeticingredientsguideStateFoodandDrugAdministrationMay12,2011Attachment:ApplicationandEvaluationofnewcosmeticingredientsguideThisguideisintendedtoguidethedeclarationofnewcosmeticingredientsandreview.
First,thedefinitionofnewcosmeticingredientsNewcosmeticrawmaterialisusedincosmeticsinthecountryforthefirsttimetheproductionofnaturalorartificialmaterials.
Second,thesecurityrequirementsofnewcosmeticingredientsNewcosmeticingredientsinthenormalandreasonableforeseeableconditionsofuseshallnotcauseharmtohumanhealth.
Toxicologicalevaluationofnewinformationoncosmeticingredientsshouldincludetoxicologicalsafetyevaluationreview,thenecessarytoxicologytestinginformationsecurityrisksandpossiblematerialsforsafetyassessmentdata.
Cosmeticsrawmaterialsaregenerallyinneedofnewtoxicologytestsfollowing:(A)acuteoralandacutedermaltoxicitytest;(B)theskinandacuteeyeirritation/corrosiontest;(C)theskinallergytest;(D)andlight-sensitiveskinphototoxicitytest(UVabsorptionpropertiesofrawmaterialshastobedonewhenthetrial);(E)mutationtest(shouldatleastincludeagenemutationtestandachromosomeaberrationtest);(F)sub-chronicoralanddermaltoxicitytest;(G)teratogenictest;(H)chronictoxicity/carcinogenicitytestcombination;(Ix)toxicokineticsanddynamicstest;(X)accordingtothecharacteristicsanduseofrawmaterials,butalsoconsiderothernecessarytests.
Ifthenewmaterialhasbeenusedincosmeticsandchemicalstructureandpropertiesofsimilarmaterials,youcanconsiderreducingsomeofthetest.
Thisguideprovidesinformationfortheprinciplerequirementsoftoxicologytests,accordingtothephysicalandchemicalpropertiesofrawmaterials,QSAR,toxicology,clinicalresearch,epidemiologyandpopulationsimilartothetoxicityofcompounds,suchasinformationapilotprojecttoincreaseorreduce.
Third,newcosmeticingredientsadministrativelicensingrequirementsfordisclosureofinformationApplyfornewcosmeticingredientscosmeticadministrativelicenseshallaccepttheadministrativelicensingrequirementstosubmitinformationreturns.
Specificrequirementsareasfollows:(A)newcosmeticrawmaterials,administrativelicensingapplicationform(B)developmentreport1MaterialsR&Dbackground,processandrelatedtechnicalinformation.
(2)thenameofrawmaterial,origin,molecularweight,molecularformula,chemicalstructure,physicalandchemicalproperties.
(1)Name:rawmaterials,includingthechemicalname(IUPACnameand/orCASname),INCInameandtheirChinesetranslation,tradenamesandCASnumbers.
Materialshouldalsoindicatethenameoftheuseofrawmaterialsspecifications.
NaturalrawmaterialsshouldalsoprovidetheLatinscientificname.
(2)Source:rawmaterialsshouldnotbeacompoundformedinthematerialduetounavoidabletechnicalreasons,theexistenceofsolvents,stabilizers,carriers,etc.
,except.
Naturalmaterialsshouldbeasinglesource,andprovidestheuseofpartsandsoon.
Allplantshavebeenallowedtobeusedascosmeticrawmaterials,notallpartsoftheplantmaterialandthenanewdeclaration.
(3)molecularweight,molecularformula,chemicalstructure:chemicalstructureshouldprovidethebasisforconfirmation(eg,NMR,elementalanalysis,massspectrometry,infraredspectra,etc.
)andanalyticalresults,shouldalsoprovidepolymerrelativetotheaveragemolecularweightanditsdistribution.
(4)physicalandchemicalpropertiesinclude:color,odor,state,solubility,meltingpoint,boilingpoint,specificgravity,vaporpressure,pHvalue,pKavalue,refractiveindex,opticalrotationandsoon.
3ingredientsincosmeticsintendeduse,scopeofuseforsecurityandtheuseoflimitedbasis,cautions,warnings,etc.
4ingredientsinaforeigncountry(region)isusedincosmeticscasedescriptions.
(C)theproductionprocessdescriptionanddiagramShouldindicatethenewcosmeticrawmaterialstoproducethemajorstepsinvolvedintheprocess,proceduresandparameters,suchasrawmaterialsshouldbelisted,thereactionconditions(temperature,pressure,etc.
),additives(catalysts,stabilizers),intermediatesandby-productsandthepreparationstepsetc.
;thecaseofnaturalextracts,shouldindicatetheprocessing,extractionmethod,extractionconditions,theuseofsolvents,mayberesidualimpuritiesorsolvent.
(D)rawmaterialqualityandsafetycontrolrequirementsShouldincludespecifications,testmethods,theremaybeasecurityrisksubstancesandcontrolmeasuresandsoon.
1.
Specificationsinclude:purityorcontentofimpurityspeciesandtheirrespectivecontent(residualmonomerandpolymercontenttobedescribed)andotherindicatorsofqualityandsafetycontrol,duetounavoidabletechnicalreasonsexistintherawmaterialsofsolvent,stabilizer,carrier,etc.
typesandtheirrespectivecontent,otherphysicalandchemicalparameters,shelflifeandstorageconditions;thecaseofnaturalplantextracts,shouldbeclearindicatorsofitsqualityandsafetycontrol.
2detectionmethods:qualitativeandquantitativematerialtestingmethods,testingmethodsimpurities.
3possiblesecurityrisksubstancesandtheircontrolmeasures.
(E)toxicologicalsafetyevaluationdata(includingrawmaterials,theremaybesecurityrisksinthesafetyassessmentofmaterialinformation)Toxicologytestdatacanbetheapplicant'stestdata,scientificliteratureanddomesticandforeigngovernmentofficialwebsite,thecontentofwebsitesofinternationalorganizations.
1applyfornewcosmeticingredients,cosmetics,newmaterialsgenerallyshouldberequiredtosubmitsafetydatatoxicologytests.
(2)oneofthefollowingcircumstances,accordingtothefollowingrequirementstosubmittoxicologytestdata.
Accordingtothecharacteristicsanduseofrawmaterials,ifnecessary,mayrequestanincreaseorreductionrelatedtoexperimentaldata.
(1)whodonothavepreservatives,sunscreens,colorantsanddyes,andfunctionalingredientsfromasafetypointofviewnotincludedinthe"HygienicStandardforCosmetics"Restrictedsubstancestablesnewcosmeticrawmaterials,shouldsubmitthefollowinginformation:1)Theacuteoralandacutedermaltoxicitytest;2)skinandacuteeyeirritation/corrosiontest;3)skinallergytest;4)andlight-sensitiveskinphototoxicitytest(UVabsorptionpropertiesofrawmaterialshastobedonewhenthetwotrials);5)mutationtest(shouldatleastincludeagenemutationtestandachromosomeaberrationtest);6)sub-chronicoralordermaltoxicitytest.
Iftherawmaterialsusedincosmetics,thepossibilityoforalintakeoflarge,shouldprovidesub-chronicoraltoxicitytest.
(2)complywiththeconditions(1),andbyforeign(regional)authoritiesoncosmeticingredientscatalogreproducesmorethanfouryears,involvesnoharmtohumanhealthmayberelatedtoliterature,shouldsubmitthefollowinginformation:1)Theacuteoralandacutedermaltoxicitytest;2)skinandacuteeyeirritation/corrosiontest;3)skinallergytest;4)andlight-sensitiveskinphototoxicitytest(UVabsorptionpropertiesofrawmaterialshastobedonewhenthetwotrials);5)mutationtest(shouldatleastincludeagenemutationtestandachromosomeaberrationtest).
(3)Whereahistoryofsafehumanconsumption,suchasdomesticandforeigngovernmentofficialoragencyorauthorityissuedbythesafetyassessmentoffoodingredientsconsideredsafeanditsextracts,theStateCounciladministrativedepartmentannouncedasbothfoodandpharmaceuticalitems,etc.
shouldsubmitthefollowinginformation:1)skinandacuteeyeirritation/corrosiontest;2)Theskinallergytest;3)andlight-sensitiveskinphototoxicitytest(UVabsorptionpropertiesofrawmaterialshastobedonewhenthetrial).
(4)byoneormorestructuralunitsconnectedbycovalentbonds,relativetotheaveragemolecularweightgreaterthan1000daltonsnewpolymersascosmeticrawmaterials,shouldsubmitthefollowinginformation:1)skinandacuteeyeirritation/corrosiontest;2)skinphototoxicitytest(UVabsorptionpropertiesofrawmaterialshastobedonewhenthetrial).
(5)Whereaforeign(regional)authoritiesevaluationconcludedthatitissafetouseincosmeticsofthenewmaterial,reportingisnotrequiredtoprovidetoxicologicaltestdata,butshouldbesubmittedtoforeigncountries(regions)toassesstheconclusionsofevaluationreportsandrelatedinformation.
Foreign(region)approvedanewcosmeticingredients,shouldbesubmittedtotheapprovalcertificate.
(F)importsnewcosmeticrawmaterials,theapplicantshallbesubmittedtotheadministrativelicensinghasbeenfiledtodeclaretheresponsibleunitsinChina,powerofattorneyandacopyoftheirreportingresponsibilitiesontheadministrativelicensingunitinChinabusinesslicenseandofficialseal.
(G)maycontributetotheadministrativelicensingandotherinformation.
Applicantsshouldbebasedonthenewmaterialpropertiesaccordingtotheaboverequestedinformation,unlesstherelevantrequirementsdonotapply.
Attachedasamplesentforscreening.
Fourth,theprincipleofnewcosmeticingredientsreview(A)fortheapplicanttosubmitthesafetyevaluationofnewcosmeticingredientsdataintegrity,reasonableandscientificconductofthereview:1safetyevaluationofinformationcontentiscompleteandconsistentinformationrequirements;2basedonwhetherthescientific,criticaldataisreasonable,analysisislogical,conclusioniscorrect;3keynewsourceofrawmaterialsofcosmeticsreview,physicalandchemicalnature,purpose,scope,andlimitedusebasis,productionprocesses,qualityandsafetycontrolrequirementsandthenecessarytoxicologicalevaluationofinformation.
(B)Thereviewconsideredcosmeticsafetyevaluationofnewrawmaterialproblems,theexpertsshouldreviewtherelevantprovisionsofcosmeticsregulatoryandscientificbasis,tomakespecificcomments.
Theapplicantwithintheprescribedtimelimitshouldprovideappropriatesafetyevaluation.
(C)Withthedevelopmentofscientificresearch,theStateFoodandDrugAdministrationhasapprovedcosmeticscanre-evaluationofnewmaterials.
Fifth,aspecialtypeofreportingandreviewofnewcosmeticrawmaterialrequirementswillbeforthcoming.
VIAbbreviations(A)IUPAC,InternationalUnionofPureandAppliedChemistry(InternationalUnionofPureandAppliedChemistry)abbreviations.
(B)CAS,theAmericanChemicalAbstractsService(ChemicalAbstractsService)abbreviations.
(C)INCI,Internationalcosmeticingredientsnamed(InternationalNomenclatureCosmeticIngredient)abbreviation.
ThisguidebytheStateFoodandDrugAdministrationresponsiblefortheinterpretation.
ThisguideisfromJuly1,2011shallcomeintoforce.
Previouslypublishedreportandreviewofnewcosmeticingredientsregulationsinconsistentwiththisguideinordertoprevailinthisguide.
BeijingTongRuiLianTechnologyCo.
,Ltd.
Tel:86-10-6428460586-10-64132180Fax:86-10-64132180E-mail:bj500@126.
combj2180@gmail.
com
207May12,2011releaseProvinces,autonomousregionsandmunicipalitiesFoodandDrugAdministration(DrugAdministration),theunit:Newcosmeticingredientstoenhancetheadministrativelicensingworktoensurequalityandsafetyofcosmeticproducts,basedon"cosmeticsHealthSupervision"anditsImplementingRulesandotherrelevantprovisionsoftheStateFoodandDrugAdministrationtodevelopa"declarationofnewcosmeticrawmaterialsandguidelinesforthereview.
"Isherebyissued,pleasecomply.
ApplicationandEvaluationofnewcosmeticingredientsguideStateFoodandDrugAdministrationMay12,2011Attachment:ApplicationandEvaluationofnewcosmeticingredientsguideThisguideisintendedtoguidethedeclarationofnewcosmeticingredientsandreview.
First,thedefinitionofnewcosmeticingredientsNewcosmeticrawmaterialisusedincosmeticsinthecountryforthefirsttimetheproductionofnaturalorartificialmaterials.
Second,thesecurityrequirementsofnewcosmeticingredientsNewcosmeticingredientsinthenormalandreasonableforeseeableconditionsofuseshallnotcauseharmtohumanhealth.
Toxicologicalevaluationofnewinformationoncosmeticingredientsshouldincludetoxicologicalsafetyevaluationreview,thenecessarytoxicologytestinginformationsecurityrisksandpossiblematerialsforsafetyassessmentdata.
Cosmeticsrawmaterialsaregenerallyinneedofnewtoxicologytestsfollowing:(A)acuteoralandacutedermaltoxicitytest;(B)theskinandacuteeyeirritation/corrosiontest;(C)theskinallergytest;(D)andlight-sensitiveskinphototoxicitytest(UVabsorptionpropertiesofrawmaterialshastobedonewhenthetrial);(E)mutationtest(shouldatleastincludeagenemutationtestandachromosomeaberrationtest);(F)sub-chronicoralanddermaltoxicitytest;(G)teratogenictest;(H)chronictoxicity/carcinogenicitytestcombination;(Ix)toxicokineticsanddynamicstest;(X)accordingtothecharacteristicsanduseofrawmaterials,butalsoconsiderothernecessarytests.
Ifthenewmaterialhasbeenusedincosmeticsandchemicalstructureandpropertiesofsimilarmaterials,youcanconsiderreducingsomeofthetest.
Thisguideprovidesinformationfortheprinciplerequirementsoftoxicologytests,accordingtothephysicalandchemicalpropertiesofrawmaterials,QSAR,toxicology,clinicalresearch,epidemiologyandpopulationsimilartothetoxicityofcompounds,suchasinformationapilotprojecttoincreaseorreduce.
Third,newcosmeticingredientsadministrativelicensingrequirementsfordisclosureofinformationApplyfornewcosmeticingredientscosmeticadministrativelicenseshallaccepttheadministrativelicensingrequirementstosubmitinformationreturns.
Specificrequirementsareasfollows:(A)newcosmeticrawmaterials,administrativelicensingapplicationform(B)developmentreport1MaterialsR&Dbackground,processandrelatedtechnicalinformation.
(2)thenameofrawmaterial,origin,molecularweight,molecularformula,chemicalstructure,physicalandchemicalproperties.
(1)Name:rawmaterials,includingthechemicalname(IUPACnameand/orCASname),INCInameandtheirChinesetranslation,tradenamesandCASnumbers.
Materialshouldalsoindicatethenameoftheuseofrawmaterialsspecifications.
NaturalrawmaterialsshouldalsoprovidetheLatinscientificname.
(2)Source:rawmaterialsshouldnotbeacompoundformedinthematerialduetounavoidabletechnicalreasons,theexistenceofsolvents,stabilizers,carriers,etc.
,except.
Naturalmaterialsshouldbeasinglesource,andprovidestheuseofpartsandsoon.
Allplantshavebeenallowedtobeusedascosmeticrawmaterials,notallpartsoftheplantmaterialandthenanewdeclaration.
(3)molecularweight,molecularformula,chemicalstructure:chemicalstructureshouldprovidethebasisforconfirmation(eg,NMR,elementalanalysis,massspectrometry,infraredspectra,etc.
)andanalyticalresults,shouldalsoprovidepolymerrelativetotheaveragemolecularweightanditsdistribution.
(4)physicalandchemicalpropertiesinclude:color,odor,state,solubility,meltingpoint,boilingpoint,specificgravity,vaporpressure,pHvalue,pKavalue,refractiveindex,opticalrotationandsoon.
3ingredientsincosmeticsintendeduse,scopeofuseforsecurityandtheuseoflimitedbasis,cautions,warnings,etc.
4ingredientsinaforeigncountry(region)isusedincosmeticscasedescriptions.
(C)theproductionprocessdescriptionanddiagramShouldindicatethenewcosmeticrawmaterialstoproducethemajorstepsinvolvedintheprocess,proceduresandparameters,suchasrawmaterialsshouldbelisted,thereactionconditions(temperature,pressure,etc.
),additives(catalysts,stabilizers),intermediatesandby-productsandthepreparationstepsetc.
;thecaseofnaturalextracts,shouldindicatetheprocessing,extractionmethod,extractionconditions,theuseofsolvents,mayberesidualimpuritiesorsolvent.
(D)rawmaterialqualityandsafetycontrolrequirementsShouldincludespecifications,testmethods,theremaybeasecurityrisksubstancesandcontrolmeasuresandsoon.
1.
Specificationsinclude:purityorcontentofimpurityspeciesandtheirrespectivecontent(residualmonomerandpolymercontenttobedescribed)andotherindicatorsofqualityandsafetycontrol,duetounavoidabletechnicalreasonsexistintherawmaterialsofsolvent,stabilizer,carrier,etc.
typesandtheirrespectivecontent,otherphysicalandchemicalparameters,shelflifeandstorageconditions;thecaseofnaturalplantextracts,shouldbeclearindicatorsofitsqualityandsafetycontrol.
2detectionmethods:qualitativeandquantitativematerialtestingmethods,testingmethodsimpurities.
3possiblesecurityrisksubstancesandtheircontrolmeasures.
(E)toxicologicalsafetyevaluationdata(includingrawmaterials,theremaybesecurityrisksinthesafetyassessmentofmaterialinformation)Toxicologytestdatacanbetheapplicant'stestdata,scientificliteratureanddomesticandforeigngovernmentofficialwebsite,thecontentofwebsitesofinternationalorganizations.
1applyfornewcosmeticingredients,cosmetics,newmaterialsgenerallyshouldberequiredtosubmitsafetydatatoxicologytests.
(2)oneofthefollowingcircumstances,accordingtothefollowingrequirementstosubmittoxicologytestdata.
Accordingtothecharacteristicsanduseofrawmaterials,ifnecessary,mayrequestanincreaseorreductionrelatedtoexperimentaldata.
(1)whodonothavepreservatives,sunscreens,colorantsanddyes,andfunctionalingredientsfromasafetypointofviewnotincludedinthe"HygienicStandardforCosmetics"Restrictedsubstancestablesnewcosmeticrawmaterials,shouldsubmitthefollowinginformation:1)Theacuteoralandacutedermaltoxicitytest;2)skinandacuteeyeirritation/corrosiontest;3)skinallergytest;4)andlight-sensitiveskinphototoxicitytest(UVabsorptionpropertiesofrawmaterialshastobedonewhenthetwotrials);5)mutationtest(shouldatleastincludeagenemutationtestandachromosomeaberrationtest);6)sub-chronicoralordermaltoxicitytest.
Iftherawmaterialsusedincosmetics,thepossibilityoforalintakeoflarge,shouldprovidesub-chronicoraltoxicitytest.
(2)complywiththeconditions(1),andbyforeign(regional)authoritiesoncosmeticingredientscatalogreproducesmorethanfouryears,involvesnoharmtohumanhealthmayberelatedtoliterature,shouldsubmitthefollowinginformation:1)Theacuteoralandacutedermaltoxicitytest;2)skinandacuteeyeirritation/corrosiontest;3)skinallergytest;4)andlight-sensitiveskinphototoxicitytest(UVabsorptionpropertiesofrawmaterialshastobedonewhenthetwotrials);5)mutationtest(shouldatleastincludeagenemutationtestandachromosomeaberrationtest).
(3)Whereahistoryofsafehumanconsumption,suchasdomesticandforeigngovernmentofficialoragencyorauthorityissuedbythesafetyassessmentoffoodingredientsconsideredsafeanditsextracts,theStateCounciladministrativedepartmentannouncedasbothfoodandpharmaceuticalitems,etc.
shouldsubmitthefollowinginformation:1)skinandacuteeyeirritation/corrosiontest;2)Theskinallergytest;3)andlight-sensitiveskinphototoxicitytest(UVabsorptionpropertiesofrawmaterialshastobedonewhenthetrial).
(4)byoneormorestructuralunitsconnectedbycovalentbonds,relativetotheaveragemolecularweightgreaterthan1000daltonsnewpolymersascosmeticrawmaterials,shouldsubmitthefollowinginformation:1)skinandacuteeyeirritation/corrosiontest;2)skinphototoxicitytest(UVabsorptionpropertiesofrawmaterialshastobedonewhenthetrial).
(5)Whereaforeign(regional)authoritiesevaluationconcludedthatitissafetouseincosmeticsofthenewmaterial,reportingisnotrequiredtoprovidetoxicologicaltestdata,butshouldbesubmittedtoforeigncountries(regions)toassesstheconclusionsofevaluationreportsandrelatedinformation.
Foreign(region)approvedanewcosmeticingredients,shouldbesubmittedtotheapprovalcertificate.
(F)importsnewcosmeticrawmaterials,theapplicantshallbesubmittedtotheadministrativelicensinghasbeenfiledtodeclaretheresponsibleunitsinChina,powerofattorneyandacopyoftheirreportingresponsibilitiesontheadministrativelicensingunitinChinabusinesslicenseandofficialseal.
(G)maycontributetotheadministrativelicensingandotherinformation.
Applicantsshouldbebasedonthenewmaterialpropertiesaccordingtotheaboverequestedinformation,unlesstherelevantrequirementsdonotapply.
Attachedasamplesentforscreening.
Fourth,theprincipleofnewcosmeticingredientsreview(A)fortheapplicanttosubmitthesafetyevaluationofnewcosmeticingredientsdataintegrity,reasonableandscientificconductofthereview:1safetyevaluationofinformationcontentiscompleteandconsistentinformationrequirements;2basedonwhetherthescientific,criticaldataisreasonable,analysisislogical,conclusioniscorrect;3keynewsourceofrawmaterialsofcosmeticsreview,physicalandchemicalnature,purpose,scope,andlimitedusebasis,productionprocesses,qualityandsafetycontrolrequirementsandthenecessarytoxicologicalevaluationofinformation.
(B)Thereviewconsideredcosmeticsafetyevaluationofnewrawmaterialproblems,theexpertsshouldreviewtherelevantprovisionsofcosmeticsregulatoryandscientificbasis,tomakespecificcomments.
Theapplicantwithintheprescribedtimelimitshouldprovideappropriatesafetyevaluation.
(C)Withthedevelopmentofscientificresearch,theStateFoodandDrugAdministrationhasapprovedcosmeticscanre-evaluationofnewmaterials.
Fifth,aspecialtypeofreportingandreviewofnewcosmeticrawmaterialrequirementswillbeforthcoming.
VIAbbreviations(A)IUPAC,InternationalUnionofPureandAppliedChemistry(InternationalUnionofPureandAppliedChemistry)abbreviations.
(B)CAS,theAmericanChemicalAbstractsService(ChemicalAbstractsService)abbreviations.
(C)INCI,Internationalcosmeticingredientsnamed(InternationalNomenclatureCosmeticIngredient)abbreviation.
ThisguidebytheStateFoodandDrugAdministrationresponsiblefortheinterpretation.
ThisguideisfromJuly1,2011shallcomeintoforce.
Previouslypublishedreportandreviewofnewcosmeticingredientsregulationsinconsistentwiththisguideinordertoprevailinthisguide.
BeijingTongRuiLianTechnologyCo.
,Ltd.
Tel:86-10-6428460586-10-64132180Fax:86-10-64132180E-mail:bj500@126.
combj2180@gmail.
com
- http://www.aqsiqccc.com/en/aqsiq/sfda-9.html相关文档
- tableswww.585ccc.com
- contactedwww.585ccc.com
- releasedwww.585ccc.com
- outstandingwww.585ccc.com
- Swanwww
- www.585ccc.com手机ccc认证查询,求网址
LOCVPS-2021年6月香港便宜vps宽带升级，充值就送代金券，其它八折优惠！
LOCVPS怎么样？LOCVPS是一家成立于2011年的稳定老牌国人商家，目前提供中国香港、韩国、美国、日本、新加坡、德国、荷兰等区域VPS服务器，所有机房Ping延迟低，国内速度优秀，非常适合建站和远程办公，所有机房Ping延迟低，国内速度优秀，非常适合做站。XEN架构产品的特点是小带宽无限流量、不超售！KVM架构是目前比较流行的虚拟化技术，大带宽，生态发展比较全面！所有大家可以根据自己业务需求...
易探云韩国云服务器仅50元/月,510元/年起
韩国云服务器哪个好?韩国云服务器好用吗?韩国是距离我国很近的一个国家，很多站长用户在考虑国外云服务器时，也会将韩国云服务器列入其中。绝大部分用户都是接触的免备案香港和美国居多，在加上服务器确实不错，所以形成了习惯性依赖。但也有不少用户开始寻找其它的海外免备案云服务器，比如韩国云服务器。下面云服务器网(yuntue.com)就推荐最好用的韩国cn2云服务器，韩国CN2云服务器租用推荐。为什么推荐租用...
#推荐# cmivps：全场7折，香港不限流量VPS，支持Windows系统
cmivps香港VPS带来了3个新消息：（1）双向流量改为单向流量，相当于流量间接扩大一倍；（2）Hong Kong 2T、Hong Kong 3T、Hong Kong 无限流量，这三款VPS开始支持Windows系统，如果需要中文版Windows系统请下单付款完成之后发ticket要求官方更改即可；（3）全场7折年付、8折月付优惠，优惠码有效期一个月！官方网站：https://www.cmivp...
www.585ccc.com为你推荐
-
乐划锁屏乐视手机如何破解锁屏密码？云爆发养兵千日用兵千日这个说法对不对newworldNew World Group是什么组织嘉兴商标注册嘉兴那里有设计商标的www.4411b.com难道那www真的4411B坏了，还是4411b梗换com鑫域明了冯媛甑夏如芝是康熙来了的第几期?mole.61.com摩尔大陆？？？？？www.03ggg.comwww.tvb33.com这里好像有中国性戏观看吧??杨丽晓博客杨丽晓是怎么 出道的www.bbb551.comHUNTA551第一个第二个妹子是谁呀？？